Overexpressing Extracellular Superoxide Dismutase Attenuation of Cerebral Vasospasm After Subarachnoid Hemorrhage in Mice
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چکیده
Matthew J. McGirt, Augusto Parra, Huaxin Sheng, Yoshinori Higuchi, Tim D. Oury, Daniel T. Overexpressing Extracellular Superoxide Dismutase Attenuation of Cerebral Vasospasm After Subarachnoid Hemorrhage in Mice Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2002 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR.0000027207.67639.1E 2002;33:2317-2323 Stroke. http://stroke.ahajournals.org/content/33/9/2317 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase.
BACKGROUND AND PURPOSE Subarachnoid hemorrhage (SAH) increases production of vascular extracellular superoxide anion (*O2-). We examined whether overexpression of murine extracellular superoxide dismutase (EC-SOD) alters SAH-induced cerebral vasospasm, oxidative stress, and neurological outcome. METHODS Mice exhibiting a 2-fold increase in vascular EC-SOD and wild-type (WT) littermates were s...
متن کاملAmelioration of vasospasm after subarachnoid hemorrhage in transgenic mice overexpressing CuZn-superoxide dismutase.
BACKGROUND AND PURPOSE To clarify the effect of superoxide dismutase (SOD) on vasospasm after subarachnoid hemorrhage (SAH), we investigated sequential changes in arterial diameter after SAH in transgenic mice overexpressing CuZn-SOD (SOD-1). METHODS SOD-transgenic mice and nontransgenic littermates (35 to 40 g) were subjected to SAH produced by endovascular perforation of left anterior cereb...
متن کاملTransgenic CuZn-superoxide dismutase inhibits NO synthase induction in experimental subarachnoid hemorrhage.
BACKGROUND AND PURPOSE The expression of inducible NO synthase (iNOS) after experimental subarachnoid hemorrhage (SAH) has been postulated to play a critical role in the pathogenesis of SAH and subsequent cerebral vasospasm. The inhibitory effect of CuZn-superoxide dismutase (CuZn-SOD) on the induction of iNOS after SAH was examined by using transgenic mice overexpressing CuZn-SOD. METHODS SO...
متن کاملSubarachnoid Hemorrhage Gene Transfer of Extracellular Superoxide Dismutase Reduces Cerebral Vasospasm After
Yoshimasa Watanabe, Yi Chu, Jon J. Andresen, Hiroshi Nakane, Frank M. Faraci and Donald Subarachnoid Hemorrhage Gene Transfer of Extracellular Superoxide Dismutase Reduces Cerebral Vasospasm After Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2003 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX ...
متن کاملGene transfer of extracellular superoxide dismutase failed to prevent cerebral vasospasm after experimental subarachnoid hemorrhage.
BACKGROUND AND PURPOSE We examined the therapeutic effect of human extracellular superoxide dismutase (ECSOD) gene transfer in the prevention of delayed cerebral vasospasm after experimental subarachnoid hemorrhage (SAH) because it was reported ECSOD relieved early-stage vasospasm. METHODS Twenty mongrel dogs were divided randomly into 4 groups to serve as control, SAH, SAH+adenovirus ECSOD (...
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